Widget powered by WhatstheScore.com

Author Topic: US Scientists edit pig DNA to make organs suitable for human transplant  (Read 118 times)

0 Members and 1 Guest are viewing this topic.

Offline yungcrux

  • Global Moderator
  • Hero Member
  • *****
  • Posts: 620
    • View Profile

Scientists in the US have managed to identify a new gene-editing technique that can remove potentially harmful DNA from the pig genome, which will allow them to use the animals' organs for human transplants. A technique named CRISPR was used by Harvard University scientists to eliminate potentially harmful DNA sequences at 62 locations within pigs.

The locations are the fragments of a virus called porcine endogenous retrovirus (PERV) within the pig genome, which is dangerous to humans. "The presence of this type of virus found in pigs... brought over a billion of dollars of pharmaceutical industry investments into developing xenotransplant methods to a standstill by the early 2000s," senior author George Church, a geneticist at Harvard University, said in a statement.

"PERVs and the lack of ability to remove them from pig DNA was a real showstopper on what had been a promising stage set for xenotransplantation," he added. However a study, published in Science, details how the scientists have managed to remove the DNA so animal organs are ready for human transplants, a notion known as xenotransplantation.

Church and his colleagues made 62 genetic edits within the pig DNA to the inactive virus ? which is not harmful to pigs. They described the new technique as "an explosive leap forward in CRISPR's capability when compared to its previous record maximum of just six simultaneous edits". When the cells were then introduced to a human host, the researchers state, the PERV infectivity rate was down by 1,000 fold.

Lead author Luhan Yang, a postdoctoral fellow at the Harvard University, added: "Our work dispelled the shadow PERVs cast on the field more than a decade ago when the virus was discovered, while renewing our faith in xenotransplantation."


Volunteers to Spend 60 Days in Bed to recreate spaceflight effects on human body

Started by mastercode

Replies: 0
Views: 186
Last post August 30, 2015, 03:48:10 PM
by mastercode
West Africa faces Highest Risk of Bat-to-Human Virus Spread

Started by yungcrux

Replies: 0
Views: 76
Last post January 08, 2016, 10:06:46 AM
by yungcrux
US Researchers Grows Human Brain in the Lab from Skin Cells [Photo]

Started by mastercode

Replies: 0
Views: 127
Last post August 20, 2015, 02:19:03 PM
by mastercode
Human Brains Are not Alike, Investigation Reveals

Started by mastercode

Replies: 0
Views: 99
Last post October 14, 2015, 12:02:21 PM
by mastercode
Scientists found way to coax peripheral nerve cells into repairing damaged

Started by legendguru

Replies: 0
Views: 121
Last post September 21, 2016, 12:44:17 AM
by legendguru