Author Topic: US Scientists Stimulate Immune System to Fight Heart Disease  (Read 353 times)

0 Members and 1 Guest are viewing this topic.

Offline legendguru

  • Global Moderator
  • Hero Member
  • *****
  • Posts: 819
  • Karma: +1/-0
    • View Profile
Loading...


Someday, your immune system may be pressed into service to fight heart disease. Researchers have discovered that a simple sugar can stimulate immune system “clean up” cells to reduce disease-causing plaque in arteries.

Marcophages are the garbage men of the body. These immune system cells mop up cellular toxins and debris that are produced through cells' normal functioning.

But scientists at Washington University School of Medicine in St. Louis wondered, what if macrophages could be pressed into service to eliminate or degrade the accumulation of plaque as well? The fatty substance collects inside blood vessels and is a leading cause of heart disease and stroke.

Cardiology researcher Babak Razani has pondered that possibility. "If you, you could imagine this, that you could somehow manipulate it to rev it up, to stimulate its function, then you could make a macrophage into a super-macrophage, one that’s really stimulated to degrade."

In a two-part study published in the journal Nature Communications, Razani and colleagues described how they manipulated and activated a genetic molecule called TFEB that goes into the nucleus of macrophages, supercharging their housekeeping skills inside cells.

Researchers then showed that a simple sugar, called trehalose, stimulated macrophages in the same way. In experiments with mice prone to atherosclerotic plaques, injection of the sugar molecule decreased plaque size by 30 percent.

"So that’s what we found here," Razani reports, "that this simple, natural compound, that is very safe, could be very atherogenic as therapy for cardiovascular disease."

In their unaltered state, macrophages try to fix damaged arteries by cleaning up cellular waste, including misshapen proteins, excess fat and dysfunction cellular structures called organelles.

But Razani says they eventually become overwhelmed by the task in people with atherosclerotic plaques, contributing to the debris problem that leads to inflammation and more disease.

Razani said supercharging macrophages with trehalose, so they resist damage and are able to continue their housekeeping function, offers a potential treatment for plaques, in addition to cholesterol-lowering drugs.

Because it’s a natural substance found in yeast, mushrooms and crustaceans, Razani said trehalose is completely safe.

Investigations found the sugar is broken down and doesn’t work when swallowed. Trehalose reduced the size of arterial plaques only when injected into mice. Other sugars did not have any effect.

So the challenge for researchers now is to find a way to turn trehalose into a form that is effective in humans to fight heart disease and possibly other health conditions like fatty liver disease and diabetes.


 

 

Ebola War: Facebook Founder, Zuckerberg, wife donate $25M to fight Ebola

Started by jchima14

Replies: 0
Views: 251
Last post October 15, 2014, 08:34:07 AM
by jchima14
Zika Funding Delay Hurt Effort to Fight Virus , says US Officials

Started by internet police

Replies: 0
Views: 257
Last post October 05, 2016, 09:58:11 AM
by internet police
Officials in San Diego County Declares Emergency to Fight Hepatitis Outbreak

Started by yungcrux

Replies: 0
Views: 215
Last post September 04, 2017, 09:48:22 AM
by yungcrux
United states heralded new phase in the fight" against Ebola

Started by internet police

Replies: 0
Views: 770
Last post February 12, 2015, 05:41:29 PM
by internet police
United States to Redirect Ebola Funds to Fight Zika

Started by newspostng

Replies: 0
Views: 238
Last post April 08, 2016, 01:20:12 AM
by newspostng
Shortage of Syringes slow down Congo's Fight Against Yellow Fever

Started by mastercode

Replies: 0
Views: 193
Last post July 06, 2016, 12:47:31 PM
by mastercode
Fashola receives FG?s N200m fund to fight Ebola

Started by admin

Replies: 0
Views: 352
Last post September 02, 2014, 04:34:34 AM
by admin
Ebola fight: MTN asks customers to donate $1 through SMS

Started by internet police

Replies: 0
Views: 300
Last post November 16, 2014, 05:05:24 PM
by internet police
How Compound in bananas could help us fight viruses Like HIV, Hepatitis and more

Started by admin

Replies: 0
Views: 188
Last post October 26, 2015, 07:07:51 AM
by admin
Government Must Act in the global fight against HIV and AIDS - Report

Started by guruslodge

Replies: 0
Views: 232
Last post December 06, 2017, 12:25:33 AM
by guruslodge